Estrogen modulates iodoacetate-induced gene expression in bovine cartilage explants
نویسندگان
چکیده
منابع مشابه
Combination Effects of Prednisolone and Interleukin-4 Protect Bovine Nasal Cartilage Explants from Interleukin-1α Induced Degradation
Background: Current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. This study was undertaken to investigate the combination effects of IL-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(MMP-1) in IL-lα-treated bovine nasal cartilage (BNC) explants. Methods: BNC explants were cultu...
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The objective of this study was to investigate the influence of matrix loss on regulating chondrocyte phenotype, and the synthesis and activation of collagenolytic enzymes. IL1 was used to enhance matrix breakdown in bovine nasal cartilage explants. Change in matrix composition and its effects on chondrocyte morphology were investigated using histochemical techniques. In bovine nasal explants, ...
متن کاملGlucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants
OBJECTIVE Glucosamine hydrochloride (GH) and chondroitin sulfate (CS) are commonly used for the treatment of osteoarthritis (OA). The aim of this study was to assess their effects, alone and in combination, on preventing aggrecan degradation and inflammation in an in vitro model of OA. DESIGN To test the effects of GH and/or CS as a preventative treatment, cartilage explants were pretreated w...
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OBJECTIVE Translation of the contact zone in articulating joints is an important component of joint kinematics, yet rarely investigated in a biological context. This study was designed to investigate how sliding contact areas affect cartilage mechanobiology. We hypothesized that higher sliding speeds would lead to increased extracellular matrix mechanical stress and the expression of catabolic ...
متن کاملEffects of Estrogen and Prolactin on Bovine BRCA1 Gene Expression
Primary cultures of bovine mammary secretory epithelial cells and spontaneously transformed mammary secretory epithelial cells were treated with estradiol 17-ß or prolactin separately and in combination with both hormones. Both estradiol and prolactin induced BRCA1 expression in the cells. Hormone induced expression of BRCA1 was highest in transformed cells. Moreover, the induction of BRCA1 gen...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2009
ISSN: 0736-0266
DOI: 10.1002/jor.21042